Senior Scientist, Discovery Biology

About Rezo Therapeutics Rezo is a different kind of biopharma company. Our mission is to dramatically increase the success rate of drug development by building a disease-agnostic, fully-integrated, network biology platform that will redefine our understanding of human disease and ability to treat it.

We are leveraging a unique integrated approach, combining capabilities in genetics, proteomics, structural biology and AI to generate deep biological insights and novel therapeutic approaches.

Located in San Francisco’s vibrant Mission Bay neighborhood, Rezo is in close proximity to UCSF, numerous urban amenities, and outdoor recreational opportunities. We recognize that realizing our mission depends as much on our people as it does on our science and are building a workplace that fosters collaboration, respect, and diversity where contributing to your team’s success is valued as highly as individual achievements. If you’re passionate about team science and breaking down barriers to progress in drug development, please consider joining us!

The Opportunity We are hiring a Senior Scientist, Discovery Biology to join Rezo’s Biology Team. In this role, you will collaborate with an interdisciplinary group combining genetics, proteomics, structural biology, and AI to tackle challenging biological questions and develop transformative therapies. This opportunity allows you to leverage your expertise in cancer biology to develop and execute cutting-edge cellular assays for target validation and compound screening. Joining Rezo at this stage provides a chance to make a meaningful impact in a fast-paced, collaborative environment.

Key Responsibilities

Develop and optimize molecular and cellular assays to study protein function in 2D/3D tumor models. Design and execute CRISPR-based genetic studies to evaluate target function and therapeutic potential. Develop and conduct cell-based functional assays to profile small molecule drugs and inform structure-activity relationships (SAR). Analyze experimental data, interpret findings, and prepare reports for internal discussions, regulatory filings. Collaborate across interdisciplinary teams and effectively communicate scientific results. Manage multiple projects efficiently in a dynamic and fast-paced setting.

Qualifications

PhD in cancer biology, or a related field with relevant postdoctoral or industry experience. Candidates with a Master’s or Bachelor’s degree with 10-12+ years of expertise, including CRISPR technologies and cancer research, are also encouraged to apply. Strong hands-on experience with 2D/3D tumor models and molecular biology techniques. Proficiency in genetic manipulation of cancer cells, including CRISPR/Cas9, RNAi, and other genome-editing tools. In-depth knowledge of the molecular and cellular mechanisms driving oncogenesis. Skilled in performing immunoblotting, proliferation/apoptosis assays, and phenotypic screening assays. Proven ability to work independently while fostering collaboration in a team environment. Excellent organizational, communication, and interpersonal skills.