Manager, FP&A

Crescent Biopharma’s vision is to build a world leading oncology company bringing the next wave of therapies for cancer patients. The Company’s clinical-stage pipeline includes its lead program, a PD-1 x VEGF bispecific antibody, as well as novel antibody-drug conjugates. By leveraging multiple modalities and established targets, Crescent aims to rapidly advance potentially transformative therapies either as single agents or as part of combination regimens to treat a range of solid tumors. For more information, visit www.crescentbiopharma.com and follow the Company on LinkedIn and X.

We are seeking a Manager of FP&A to support corporate and program level planning, budgeting, and forecasting. This individual will partner closely with R&D, Program Management, Clinical, Tech Ops, and G&A teams to deliver high quality financial insights, support decision making, and ensure disciplined financial management in a dynamic, science-driven environment.

This role is ideal for someone who thrives in high growth biotech, can balance strategic thinking with hands on execution, and is excited to build scalable FP&A processes. Please note, this person must be local to the Waltham, MA office and have experience in the life sciences, biotech FP&A-space.

Responsibilities

Lead the annual operating plan, long-range planning (LRP), and quarterly forecasting cycles across all functions Build driver based financial models to support forecasting accuracy and scenario analysis Support implementation and optimization of ERP and planning tools to build scalable FP&A reporting infrastructure, including dashboards, forecast templates, and process improvements Prepare monthly and quarterly financial reporting packages for leadership, highlighting key variances, trends, and actionable insights Partner with Program Management and functional leads to manage cross-functional program budgets and timelines Support accruals related to external CRO/CMO partners, milestone based spend, and clinical site activity Partner with Accounting on monthly close, accruals, cost center reporting, and flux analysis Support headcount planning, hiring forecasts, and workforce modeling in partnership with HR and hiring managers Assist with vendor contract reviews for financial accuracy and budget alignment

Education & Experience Bachelor’s degree in Finance, Accounting, Economics, or related field. 6+ years of progressive FP&A or Finance experience, ideally within biotech or pharma Experience supporting R&D, clinical development, or other multiprogram environments Experience with biotech planning cycles (e.g., program budgeting, CRO/CMO forecasting) preferred Familiarity with ERP systems, planning tools, and business intelligence platforms (e.g., NetSuite, Adaptive Insights a plus) Demonstrated ability to partner cross-functionally and communicate complex concepts clearly Ability to manage competing priorities and operate in a fast-paced, high-growth environment Highly analytical with strong attention to detail Proactive problem solver who anticipates needs Strong interpersonal skills and business judgment Collaborative team player

What We Offer Opportunity to join a mission-driven team where you'll contribute to impactful work, take on varied responsibilities, and grow quickly in a dynamic environment Competitive compensation, including base salary, performance bonus, and equity 100% employer-paid benefits package Flexible PTO; also, two, one-week company-wide shutdowns each year A commitment to your professional development, with access to resources, mentorship, and growth opportunities